søndag den 22. januar 2017

Pyruvate and ME/POTS

Fluge, Mella et al. have shown that ME is associated with defective oxidative metabolism - most likely involving impaired pyruvate dehydrogenase function (1).

Expression of the protein mitochondrial pyruvate carrier 2 (MCC2) has been found downregulated in ME (2)

The gene similar to pyruvate kinase-isozymes M1/M2 (PKM2) has been found epigenetic changed (hypermethylated) in ME (3).

Immunoreactive proteins against IgGs from POTS patients (4, 5):

  • ODPB, pyruvate dehydrogenase E1 component subunit beta.
  • KPYM, pyruvate kinase isoenzyme M1.
  • PDHX, pyruvate dehydrogenase protein X component.
  • PKM2, pyruvate kinase isozymes M1/M2
References:

  1.  Fluge et al: Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy / chronic fatigue syndrome. JCI Insight. 2016; 1(21):e89376. Doi 10.1172/jci.insight.89276
  2. Ciregia et al.
    Translational Psychiatry (2016), 6, e904
    doi:10.1038/tp.2016.184
  3. Vega et al. DNA methylation Modifications associated with CFS. Plos One, aug 2014, vol 9, Issue 8, e104757
  4. Wang et al: Autoimmunoreactive IgGs from patients with POTS. Prot. Clin. Appl. 2012, 6, 1-11.
  5. Wang et al: Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with POTS. doi: 10.1016/j.trsl.2013.03.002

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